Cellular signaling in health and disease by Martin Beckerman

Cover of: Cellular signaling in health and disease | Martin Beckerman

Published by Springer in Dordrecht, New York .

Written in English

Read online

Subjects:

  • Cellular signal transduction,
  • Pathology, Cellular,
  • Signal Transduction -- physiology,
  • Metabolic Syndrome X -- metabolism,
  • Neoplasms -- metabolism,
  • Neurodegenerative Diseases -- metabolism

Edition Notes

Includes bibliographical references and index.

Book details

StatementMartin Beckerman.
SeriesBiological and medical physics, biomedical engineering, Biological and medical physics, biomedical engineering
Classifications
LC ClassificationsRB25 .B38 2009
The Physical Object
Paginationxvii, 470 p. :
Number of Pages470
ID Numbers
Open LibraryOL24079834M
ISBN 100387981721, 038798173X
ISBN 109780387981727, 9780387981734
LC Control Number2009900943

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Cellular Signaling in Health and Disease summarizes our current understanding of these regulatory networks in the healthy and diseased states, showing which molecular components might be prime targets for drug interventions. This is accomplished by presenting models that explain in mechanistic, molecular detail how a particular part of the.

These diseases, all associated with increasing age of an individual, have proven to be remarkably complex and difficult to treat. This is because, in large measure, when the cellular signaling pathways responsible for maintaining homeostasis and health of the body become dysregulated, they generate equally stable disease states.

"The Cell Signaling Collection consists of four independent volumes which reprint articles from the second edition of the carefully selected to alert medical and biological scientists to recent developments in the study of cellular signaling. This volume contains 57. Download Citation | On Jan 1,Martin Beckerman and others published Cellular Signaling in Health and Disease | Find, read and cite all the research you need on ResearchGateAuthor: Martin Beckerman.

The course thus provides the student with in-depth knowledge on the complexity of cellular signaling and how aberrant signaling processing causes developmental disorders and diseases, such as congenital heart defects, neurological disorders, kidney diseases, metabolic diseases, obesity, fibrosis, tumorigenesis and cancer.

Cellular Endocrinology in Health and Disease describes the underlying basis of endocrine function, Cellular signaling in health and disease book an important tool to understand the fundamentals of endocrine diseases.

Delivering a comprehensive review of the basic science of endocrinology, from cell biology to human disease, this work explores and dissects the function of a number.

Cellular Endocrinology in Health and Disease describes the underlying basis of endocrine function, providing an important tool to understand the fundamentals of endocrine diseases. Delivering a comprehensive review of the basic science of endocrinology, from cell biology to human disease, this work explores and dissects the function of a number of cellular systems.

This review addresses the current understanding of the role of cAMP metabolism and consequent cAMP signaling pathway(s) in the context of liver health and disease. The cAMP pathway is extremely sophisticated and complex with specific cellular functions dictated by numerous factors such abundance, localization and degradation by.

Akt signalling in Cellular signaling in health and disease book and disease Cell Signal. Oct;23(10) doi: /g Epub May Authors Ingeborg Hers 1, Emma E Vincent, Jeremy M Tavar é. Affiliation 1 School of Physiology.

In complex tissues, many of these sensing events occur simultaneously. Thus, the downstream signaling pathways need to be integrated so that an appropriate cellular inflammatory response can be initiated.

In addition, the inflammasome defines the molecular and cellular processes of inflammation in response to microbial infection. Cellular senescence is important for ensuring normal development and organism fitness against diseases including cancer. Meanwhile, accumulation of senescent cells during aging can be detrimental, contributing to age-related diseases.

This review discusses recent advances in understanding the functional significance of senescence in these contexts and the potential translational impact. Many cellular functions are regulated by calcium (Ca(2+)) signals that are generated by different signaling pathways.

One of these is the inositol 1,4,5-trisphosphate/calcium (InsP3/Ca(2+)) signaling pathway that operates through either primary or modulatory mechanisms. This book summarizes the functioning of complex signaling pathways in different tissues and organs of the body in both health and disease.

Containing over figures, it presents the latest research findings as a guide to drug design and tissue engineering. This book explains the fundamental concepts and roles of co-signal molecules and presents the latest information on co-stimulation.

Clinical applications in autoimmune disease, neurological disorders, transplantation, graft-versus-host disease, and cancer immunotherapy are discussed.

Authors highlight several promising discoveries in the field of calcium signaling that provide new information about both genetic and acquired pathologies.

Their discussions will give you new insights into the underlying causes of congenital and acquired diseases and point the way to new, even more promising research and therapies. Cellular Signal Processing is intended for use in signal transduction courses for undergraduate and graduate students.

It offers a unifying view of cell signaling that is based on the concept of protein interactions acting as sophisticated data processing networks that govern intracellular and extracellular communication.

The content is guided by three major principles that are central to. Cell-surface receptors activate intracellular signaling pathways and so convert an extracellular signal into an intracellular one that then transmits the signal onward.

The signal is converted into different biochemical forms, distributed to different sites in the cell, and sustained and amplified as it proceeds toward its various destinations. The text is organized by three key topics central to signal transduction: the protein network, its energy supply, and its evolution.

It covers all important aspects of cell signaling, ranging from prokaryotic signal transduction to neuronal signaling, and also highlights the clinical aspects of cell signaling in health and disease.

These diseases, all associated with increasing age of an individual, have proven to be remarkably complex and difficult to treat. This is because, in large measure, when the cellular signaling pathways responsible for maintaining homeostasis and health of the body become dysregulated, they generate equally stable disease : Springer New York.

Cell Signalling Biology Michael J. Berridge Module 12 Signalling Defects and Disease 12 1 Module 12 Signalling Defects and Disease Synopsis A large number of diseases are caused by defects in signalling pathways.

The nature of these defects and how they are induced varies enormously. Pathogenic organisms and viruses, many of which can. Amyloids Are an Essential Ingredient in Many Diseases 12 Reactive Oxygen and Nitrogen Species Carry Out Signaling in Ways That Contribute to Health and Disease 15 Further Reading 15 2 Energy Balance 19 Hormonal Signaling by the Endocrine Pancreas 21 In Response to Signals from the Pancreas, the Liver Maintains.

It includes coverage of all important aspects of cell signaling, ranging from prokaryotic signal transduction to neuronal signaling.

It also highlights the clinical aspects of cell signaling in health and disease Medical books Cellular Signal Processing: An Introduction to the Molecular Mechanisms of Signal Transduction. Book Description. Interest in the role of extracellular vesicles (microvesicles and exosomes) is expanding rapidly.

It is now apparent that far from being merely cellular debris, these vesicles play a key role in cell-to-cell communication and signaling.

Moreover, they are significantly elevated in a number of diseases. A New Paradigm for Understanding Health and Disease This new paradigm, described in my upcoming book, Dr. Lieff gives a wealth of examples for his thesis that this cellular signaling is the basis of life. It is a must read for anyone seeking to understand modern biology and advanced medical science.

It is equally important for those of. In biology, cell signaling (cell signalling in British English) is part of any communication process that governs basic activities of cells and coordinates multiple-cell actions.

The ability of cells to perceive and correctly respond to their microenvironment is the basis of development, tissue repair, and immunity, as well as normal tissue homeostasis.

The mechanistic target of Rapamycin (mTOR) is a ubiquitously-conserved serine/threonine kinase, which has a central function in integrating growth signals and orchestrating their physiologic effects on cellular level.

mTOR is the core component of differently composed signaling complexes that differ in protein composition and molecular targets. Cell signaling is vital for health because it ensures things like immune function, tissue repair, cell development, hormone operations, and essentially every single bodily process.

Inside the cell, mitochondria create these redox signaling molecules which enable communication between one. The unfolded protein response and cellular senescence. A review in the theme: cellular mechanisms of endoplasmic reticulum stress signaling in health and disease Am J Physiol Cell Physiol.

Mar 15;(6):C doi: /ajpcell Epub Dec Authors. CiteScore: ℹ CiteScore: CiteScore measures the average citations received per peer-reviewed document published in this title.

CiteScore values are based on citation counts in a range of four years (e.g. ) to peer-reviewed documents (articles, reviews, conference papers, data papers and book chapters) published in the same four calendar years, divided by the number of.

A reference on cellular signaling processes, the third edition of Signal Transduction continues in the tradition of previous editions, in providing a historical overview of how the concept of stimulus-response coupling arose in the early twentieth century and shaped our current understanding of the action of hormones, cytokines, neurotransmitters, growth factors and adhesion molecules.

The endocannabinoid system with cannabinoid receptors, specifically cannabinoid receptor type 1 (CB1R), and their endogenous activators, the endocannabinoids, has emerged as an important neuromodulator system.

Our understanding of the endocannabinoid system has significantly advanced in limbic system areas such as the hippocampus and the amygdala.

However, the study of this signaling. TY - CHAP. T1 - PTEN and cell signaling in health and disease. AU - Sur, Swastika. AU - Agrawal, Devendra K. PY - Y1 - N2 - PTEN (Phosphatase and Tensin homologue) is a aa long dual specificity phosphatase and member of the broad protein tyrosine phosphatase family, which has both lipid and protein phosphatase : Swastika Sur, Devendra K.

Agrawal. She has shown that these oxidants initiate cell stress signaling responses and death pathways including apoptosis. Vissers is the author or co-author of more than peer reviewed journal articles, book chapters and coference proceedings.

Mark Hampton and Tony Kettle are also both professors at University of Otago in Christchurch. Nitric Oxide Balance in Health and Diseases: Implications for New Treatment Strategies Musbau A.

Akanji 1, Anne A. Adeyanju 2, Damilare Rotimi 3, Oluyomi S. Adeyemi 3. The Steroid Hormones and Receptros in Health and Disease Conference - Jointly hosted by FASEB and the International Committee on Rapid Responses to Steroid Hormones (RRSH) May| Dorado, Puerto Rico ; The TGF-ß Superfamily Conference: Signaling in Development and Disease July| Malahide, Ireland.

Required reading for anyone involved in cell signaling research with articles written and edited by experts in the field. This title covers disease states such as lymphoid leukemia, breast cancer, pulmonary fibrosis, systemic sclerosis, andinflammatory bowel disease, along with up-to-date research on signaling systems and mutations in transcription factors that provide new.

Blog. How to create a video lesson on Prezi Video and prepare for next year; 7 new things you can do with Prezi Video to support online learning.

The role of lysine linked polyubiquitylation in diseases has emerged only recently. Under physiological conditions, this process does not seem to be involved in the classical protein degradation by the proteasome, but it is involved in the regulation of intracellular signaling, DNA damage response, cellular trafficking, and lysosomal targeting.

The overall idea of cancer is that a cell grows and divides erratically on its own, even without a cell signal, resulting in uncontrolled cell growth. The cell cannot die either, causing a build up of excess cells in a certain area c.

Such an excess cells is known as a tumor. Cancer is due to multiple cell signaling. The Laboratory of Immune System Biology (LISB) is focused on the basic genetics, molecular biology, and cell biology of the immune system, as well as on human disease informed by these more basic studies.

How dysregulation of the immune system results in immunodeficiencies, autoimmunity, inflammation, allergy, chronic infections, and lymphoproliferative diseases and what strategies might. NF-kB Signaling in Health and Disease Gökhan 1,2,3, Cildir,1,2,4 Kee Chung Low,1,4 and Vinay Tergaonkar * Noncanonical NF-kB signaling differs from canonical NF-kB signaling by being activated through different cell surface receptors, cytoplasmic adaptors, and NF-kB dimers.

Under normal physiological conditions, this noncanonical path-way.Cellular communication is an umbrella term used in biology and more in depth in biophysics, biochemistry and biosemiotics to identify different types of communication methods between living cellulites.

Some of the methods include cell signaling among others. This process allows millions of cells to communicate and work together to perform important bodily processes that are necessary for survival.Department of Public Health, Genetic Disease Screening Program, for Sickle Cell Disease Research Foundation, Paula Haddow, MAT, Corn Education Committee, suggestions during production of the book, modeled for the illustrations, and who were the inspiration for the project.

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